Chlorosulfonic acid → 3-Bromo-4-(trifluoromethoxy)benzenesulfonyl chloride

HRID 870343노트

반응식

HRID 870343 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][C:9]([F:12])([F:11])[F:10].[Cl:13][S:14](O)(=[O:16])=[O:15]>ClCCl.CCCCCCC.ClCCl>[Br:1][C:2]1[CH:7]=[C:6]([S:14]([Cl:13])(=[O:16])=[O:15])[CH:5]=[CH:4][C:3]=1[O:8][C:9]([F:11])([F:10])[F:12]

참가 물질

5

반응물 2

HCID 24638Chlorosulfonic acidHCID 27772661-Bromo-2-(trifluoromethoxy)benzene

생성물 1

HCID 509980203-Bromo-4-(trifluoromethoxy)benzenesulfonyl chloride수율 77.7%

시약·촉매·용매 2

HCID 6344Dichloromethane용매3회HCID 21907733Dichloromethane heptane용매

실험 절차

2.0 g of 1-bromo-2-(trifluoro-methoxy)benzene (8.3 mmol) were dissolved in 30 ml of dichloromethane. At 0-5° C., 1.06 g of chlorosulfonic acid (9.13 mmol), dissolved in 3 ml of dichloromethane, were added dropwise. The reaction mixture was stirred for 30 min at room temperature. Additional 5.5 equivalents of chlorosulfonic in dichloromethane were added to drive the reaction to completion. Standard work-up was followed and silica gel chromatography with n-heptane-dichloromethane (6:4) as eluent gave 2.19 g of the title compound.

후처리

  1. additionwere added dropwise
  2. customthe reaction to completion

출처 및 근거

ORD 기록
ord-a7097275b96e462289c2007119b09759
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969552B2

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