4-((S)-2-Fluoro-1-methyl-ethyl)-benzenesulfonyl chloride → N-{7-[4-((S)-2-Fluoro-1-methyl-ethyl)-benzenesulfonylamino]-3,4-dihydro-2H-pyrano[3,2-b]pyridin-3-yl}-propionamide

참여 물질

역할	이름	HCID	투입량
반응물	4-((S)-2-Fluoro-1-methyl-ethyl)-benzenesulfonyl chloride	HCID 53628600	—
반응물	N-(7-amino-3,4-dihydro-2H-pyrano[3,2-b]pyridin-3-yl)propionamide	HCID 68912527	—
용매	Pyridine methylene chloride	HCID 21875418	—
생성물	N-{7-[4-((S)-2-Fluoro-1-methyl-ethyl)-benzenesulfonylamino]-3,4-dihydro-2H-pyrano[3,2-b]pyridin-3-yl}-propionamide	HCID 68916577	—

반응 단계

Following the same procedure as described in example 31.5, a portion of crude N-(7-amino-3,4-dihydro-2H-pyrano[3,2-b]pyridin-3-yl)-propionamide (95 mg, 0.43 mmol) in CH2Cl2/pyridine 9/1 (10 ml) was treated with 4-((S)-2-fluoro-1-methyl-ethyl)benzenesulfonyl chloride (132 mg, 0.55 mmol). Purification by flash column chromatography (CH2Cl2:MeOH, 97:3) gave the title compound (100 mg, 55% for step 31.4 and this step) as a gum.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08969552B2
출처 데이터셋	uspto-grants-2015_03
ORD ID	ord-c0f532e3a84147a5b3e01792998d92fe
출처 메모	uspto-grants-2015_03