1,1'-Carbonyldiimidazole → N-pent-4-ynylimidazole-1-carboxamide

HRID 870602

반응식

HRID 870602 반응식
[C:1]([N:8]1[CH:12]=[CH:11]N=C1)([N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)=[O:2].[CH2:13](N)[CH2:14][CH2:15]C#C>ClCCl>[CH2:12]([NH:8][C:1]([N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)=[O:2])[CH2:11][CH2:15][C:14]#[CH:13]

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 641001Pent-4-yn-1-amine

생성물 1

HCID 86726568N-pent-4-ynylimidazole-1-carboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Add 1,1′-carbonyldiimidazole (0.539 mg 1.05 equiv; 3.26 mmoles) slowly portion wise to a −78° C. solution of 4-pentyn-1-amine (0.258 mL; 1.0 equiv; 3.10 mmoles) in dichloromethane (10 mL). Allow the reaction to warm to ambient temperature and stir for 72 hours. Use the solution directly for subsequent chemistry: MS (m/z): 178(M+1).

후처리

  1. customthe reaction

출처 및 근거

ORD 기록
ord-2cdac2a027ef46f3aa5b16dba1c0cc25
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969555B2

연결된 노트

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