반응식
C(N(CC)CC)C.[CH2:8]([NH2:13])[CH2:9][CH2:10][C:11]#[CH:12].Cl[CH2:15][C:16]([N:18]1[CH2:37][CH2:36][C:21]2[N:22]=[C:23]([NH:26][CH:27]3[CH2:35][C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH2:28]3)[N:24]=[CH:25][C:20]=2[CH2:19]1)=[O:17]>O1CCCC1>[CH2:28]1[C:29]2[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:35][CH:27]1[NH:26][C:23]1[N:24]=[CH:25][C:20]2[CH2:19][N:18]([C:16](=[O:17])[CH2:15][NH:13][CH2:8][CH2:9][CH2:10][C:11]#[CH:12])[CH2:37][CH2:36][C:21]=2[N:22]=1참가 물질
5
반응물 3
생성물 1
시약·촉매·용매 1
반응 조건
- 온도
- 55 °C
실험 절차
Add triethylamine (0.434 mL; 2.0 equiv; 3.12 mmoles) followed by 4-pentyn-1-amine (0.194 mL; 1.50 equiv; 2.34 mmoles) to a solution of 2-chloro-1-[2-(2,3-dihydro-1H-inden-2-ylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]ethanone (0.534 g; 1.0 equiv; 1.56 mmoles) in tetrahydrofuran (5.19 mL). Stir for 48 hours at 55° C. The solution was directly concentrated to afford 1-[2-(indan-2-ylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-2-(pent-4-ynylamino)ethanone (0.606 g; 100%): MS (m/z): 390(M+1).
후처리
- concentrationThe solution was directly concentrated
출처 및 근거
- ORD 기록
- ord-6fad47a17cd54d89bf4e164bea2acd8b
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08969555B2
연결된 노트
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