Trifluoroacetic acid → 6-Chloro-5-methylpyridazin-3-amine
반응식
[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8]CC2C=CC(OC)=CC=2OC)=[CH:4][C:3]=1[CH3:20].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH2:8])=[CH:4][C:3]=1[CH3:20]참가 물질
4
실험 절차
To a solution of (6-chloro-5-methyl-pyridazin-3-yl)-(2,4-dimethoxy-benzyl)-amine from above (680 mg) in DCM (8 ml) was added TFA (8 ml). The resulting solution was allowed to stand for overnight. The mixture was concentrated to give the titled compound which was used directly for next step.
후처리
- concentrationThe mixture was concentrated
출처 및 근거
- ORD 기록
- ord-4179f113de524718b26d2b53cccacf59
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08969565B2
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