4-Amino-2-methylbutan-2-ol → 4-((3-Bromoimidazo[1,2-b]pyridazin-6-yl)amino)-2-methylbutan-2-ol

반응식

[Br:1][C:2]1[N:6]2[N:7]=[C:8](F)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.[NH2:12][CH2:13][CH2:14][C:15]([CH3:18])([OH:17])[CH3:16]>>[Br:1][C:2]1[N:6]2[N:7]=[C:8]([NH:12][CH2:13][CH2:14][C:15]([CH3:18])([OH:17])[CH3:16])[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1

참가 물질

반응물 2

HCID 156491734-Amino-2-methylbutan-2-ol

HCID 866963183-Bromo-6-fluoroimidazo[1,2-b]pyridazine

생성물 1

HCID 866964084-((3-Bromoimidazo[1,2-b]pyridazin-6-yl)amino)-2-methylbutan-2-ol수율 82%

실험 절차

The 3-bromo-6-fluoroimidazo[1,2-b]pyridazine was reacted with 4-amino-2-methylbutan-2-ol using the same reaction conditions as described in example 5.6.42, Part A to obtain 82% product.

후처리

customthe same reaction conditions

출처 및 근거

ORD 기록: ord-eb7eb12d38d64454b0a7918041451a35
출처 데이터셋: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08969565B2

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