2-(Cyclopentyloxy)ethylamine → 3-bromo-N-(2-(cyclopentyloxy)ethyl)imidazo[1,2-b]pyridazin-6-amine

반응식

[CH:1]1([O:6][CH2:7][CH2:8][NH2:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:10][C:11]1[N:15]2[N:16]=[C:17](F)[CH:18]=[CH:19][C:14]2=[N:13][CH:12]=1>>[Br:10][C:11]1[N:15]2[N:16]=[C:17]([NH:9][CH2:8][CH2:7][O:6][CH:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)[CH:18]=[CH:19][C:14]2=[N:13][CH:12]=1

참가 물질

반응물 2

HCID 167835712-(Cyclopentyloxy)ethylamine

HCID 866963183-Bromo-6-fluoroimidazo[1,2-b]pyridazine

생성물 1

HCID 866964223-bromo-N-(2-(cyclopentyloxy)ethyl)imidazo[1,2-b]pyridazin-6-amine수율 69%

실험 절차

The 2-(cyclopentyloxy)ethanamine was reacted with 3-bromo-6-fluoroimidazo[1,2-b]pyridazine, using the amine displacement conditions described in example 5.6.42, part A to afford 69% product.

출처 및 근거

ORD 기록: ord-5de4ae2ff2f047b387ab4ed61f7df315
출처 데이터셋: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08969565B2

반응 노트

불러오는 중…