Pyridine → HCID 86696428, 화합물
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([NH2:11])=[CH:9][N:10]=2)[N:7]=1.[Br:12][CH2:13][CH2:14][CH2:15][C:16](Cl)=[O:17].N1C=CC=CC=1>C1COCC1.CCOC(C)=O>[Br:12][CH2:13][CH2:14][CH2:15][C:16]([NH:11][C:8]1[N:6]2[N:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1)=[O:17]참가 물질
6
실험 절차
To 1.0 g (5.930 mmol) of 6-chloroimidazo[1,2-b]pyridazin-3-amine dissolved in 15 mL of THF was added 4-bromobutanoyl chloride (1.21 g, 6.52 mmol) and pyridine (0.96 mL, 11.86 mmol). This mixture was stirred for 1 hr at rt, and then diluted with 30 mL EtOAc and quenched with aq. NaHCO3. The organic layer was separated and washed with brine, dried over MgSO4, and concentrated. The solid obtained (1.39 g, 74% yield) was pure enough to be used for the next step without further purification.
후처리
- customquenched with aq. NaHCO3
- customThe organic layer was separated
- washwashed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated
- customThe solid obtained (1.39 g, 74% yield)
- customto be used for the next step without further purification
출처 및 근거
- ORD 기록
- ord-07cadc98406d4817a2c9c53c3161d30a
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08969565B2
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