HCID 86689231, 화합물 → HCID 71621925, 화합물

HRID 871022노트

반응식

HRID 871022 반응식
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-])=[O:14])[CH:8]=2)[C:3]=1[C:16]([NH2:18])=[O:17].[H][H]>CO.[Pt]=O>[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][OH:14])[CH:8]=2)[C:3]=1[C:16]([NH2:18])=[O:17]

참가 물질

5

반응물 2

HCID 86689231HCID 86689231, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 71621925HCID 71621925, 화합물수율 67.3%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매2회HCID 887Methanol용매

실험 절차

A mixture of 5-amino-3-(3-nitrophenyl)isothiazole-4-carboxamide (50 mg, 0.19 mmol) and platinum oxide (20 mg, 0.088 mmol) in 5 mL MeOH was hydrogenated under 60 PSI hydrogen. After 5 hours an additional catalytic amount of platinum oxide was added and the reaction continued for 67 hours. The reaction mixture was filtered using Celite and the filter bed rinsed with 40% MeOH/CHCl3. The filtrate was evaporated to give 32 mg of yellow solid. Then 22 mg of this material was chromatographed eluting with CHCl3/MeOH to give the title compound as a pale yellow solid (10.2 mg).

후처리

  1. filtrationThe reaction mixture was filtered
  2. washthe filter bed rinsed with 40% MeOH/CHCl3
  3. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-b6951dc5e0bc420f9bf66f7455cb855c
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969583B2

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