Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid → Tert-butyl 4-(4-(2-(pyridin-4-yl)thiazole-4-carboxamido)isothiazol-5-yl)piperazine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid | HCID 716091 | — |
| 반응물 | 2-(2,6-Difluorophenyl)-1,3-thiazole-4-carboxylic acid | HCID 24278454 | — |
| 반응물 | Tert-butyl 4-(4-aminoisothiazol-5-yl)piperazine-1-carboxylate | HCID 86720862 | — |
| 생성물 | Tert-butyl 4-(4-(2-(pyridin-4-yl)thiazole-4-carboxamido)isothiazol-5-yl)piperazine-1-carboxylate | HCID 86720861 | 89.3% |
반응 단계
Following the procedure described in Step (3) of Example 6, and substituting Compounds 2E and 6D8 with 2-(pyridin-4-yl)thiazole-4-carboxylic acid (19E) (58 mg, 0.28 mmol) and tert-butyl 4-(4-aminoisothiazol-5-yl)piperazine-1-carboxylate (31D3) (80 mg, 0.28 mmol) respectively, Compound 31A (120 mg, 0.25 mmol) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08969584B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-74bcf30c1b6648f49792e395565db9c8 |
| 출처 메모 | uspto-grants-2015_03 |