Methanimidamide, hydrochloride (1:1) → HCID 178496103, 화합물

HRID 871319

반응식

HRID 871319 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][O:15][CH3:16])=[CH:8][C:3]=1[C:4](OC)=[O:5].Cl.[CH:18](N)=[NH:19]>CCO>[OH:5][C:4]1[C:3]2[C:2](=[CH:11][CH:10]=[C:9]([O:12][CH2:13][CH2:14][O:15][CH3:16])[CH:8]=2)[N:1]=[CH:18][N:19]=1

참가 물질

4

반응물 2

HCID 10313058Methanimidamide, hydrochloride (1:1)HCID 61305437Methyl 2-amino-5-(2-methoxyethoxy)benzoate

생성물 1

HCID 178496103HCID 178496103, 화합물수율 95.2%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
130 °C

실험 절차

To methyl 2-amino-5-(2-methoxyethoxy)benzoate (964 mg, 4.2 mmol) in absolute EtOH (25 mL) was added formamidine hydrochloride (1.4 g, 17.2 mmol) and the mixture heated in a sealed tube at 130° C. overnight. The mixture was cooled to room temperature and filtered to give 4-hydroxy-6-(2-methoxyethoxy)quinazoline (871 mg, 4.0 mmol, 95%). 1H NMR (300 MHz, DMSO-d6) δ 8.42 (br s, 1H), 7.99 (s, 1H), 7.61 (d, 1H), 7.50 (d, 1H), 7.43 (dd, 1H), 4.21 (dd, 2H), 3.70 (dd, 2H), 3.32 (s, 3H); LC-MS (ESI) m/z 221 (M+H)+.

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-7af26736a349400a8e5ee103b3e28c34
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969587B2

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