Trimethylsilyldiazomethane → HCID 53710760, 화합물

HRID 871592노트

반응식

HRID 871592 반응식
[CH3:1][Si](C=[N+]=[N-])(C)C.[F:8][C:9]([F:16])([F:15])[C:10](=[O:14])[CH2:11][C:12]#[N:13]>C(OCC)C>[F:8][C:9]([F:16])([F:15])[C:10]([O:14][CH3:1])=[CH:11][C:12]#[N:13]

참가 물질

4

반응물 2

HCID 167693TrimethylsilyldiazomethaneHCID 138435404,4,4-Trifluoro-3-oxobutanenitrile

생성물 1

HCID 53710760HCID 53710760, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
0 °C

실험 절차

(Trimethylsilyl)diazomethane (21 mL, 2M in diethyl ether) was added dropwise to a solution of 4,4,4-trifluoro-3-oxobutanenitrile (3.79 g, 26 mmol) in anhydrous diethyl ether (25 mL) previously cooled to 0° C. The resulting mixture was allowed to slowly warm to room temperature and stirred overnight. The solvent was removed under reduced pressure to give 4,4,4-trifluoro-3-methoxybut-2-enenitrile, which was directly used in the next step without further purification. 1H NMR (300 MHz, CDCl3) d 5.00 (s, 1H), 4.16 (s, 3H).

후처리

  1. temperatureto slowly warm to room temperature
  2. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-4738ab93db644391bb6b0598d74a380a
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969587B2

반응 노트

불러오는 중…