m-Tolylhydrazinium(1+) chloride → HCID 66876804, 화합물

HRID 871741

반응식

HRID 871741 반응식
Cl.[C:2]1([CH3:10])[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][NH2:9])[CH:3]=1.[F:11][C:12]([F:19])([F:18])[C:13](=O)[CH2:14][C:15]#[N:16]>>[C:2]1([CH3:10])[CH:7]=[CH:6][CH:5]=[C:4]([N:8]2[C:15]([NH2:16])=[CH:14][C:13]([C:12]([F:19])([F:18])[F:11])=[N:9]2)[CH:3]=1

참가 물질

3

반응물 2

HCID 71562m-Tolylhydrazinium(1+) chlorideHCID 138435404,4,4-Trifluoro-3-oxobutanenitrile

생성물 1

HCID 66876804HCID 66876804, 화합물수율 22%

실험 절차

Following the procedure in Example 161A Step 3, m-tolylhydrazine hydrochloride (1.15 g, 7.30 mmol) and 4,4,4-trifluoro-3-oxobutanenitrile (1.0 g, 7.30 mmol) were reacted to give 1-m-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-amine (380 mg, 1.57 mmol, 22%). 1H NMR (300 MHz, DMSO-d6) δ 7.60-7.20 (m, 4H), 5.82-5.61 (m, 3H), 2.59 (s, 3H); LC-MS (ESI) m/z 242 (M+H)+.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-5e624a5c794b4680b1e0271d7764a5bd
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08969587B2

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