Cyclopentylamine → 3-chloro-N-cyclopentylbenzamide

HRID 872265노트

반응식

HRID 872265 반응식
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11](Cl)=[O:12]>>[Cl:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([NH:6][CH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:12]

참가 물질

3

반응물 2

HCID 2906CyclopentylamineHCID 69252Benzoyl chloride, 3-chloro-

생성물 1

HCID 41244353-chloro-N-cyclopentylbenzamide수율 92%

실험 절차

Employing 0.16 g (1.9 mmol) of cyclopentylamine and 0.51 g, (2.9 mmol) of 3-chloro-benzoyl chloride in the procedure described above and elution with CHCl3/MeOH/Et3N (9.8:0.1:0.1) gave white crystals in 92% yield).

후처리

  1. washelution with CHCl3/MeOH/Et3N (9.8:0.1:0.1)
  2. customgave white crystals in 92% yield)

출처 및 근거

ORD 기록
ord-542791f0f382422f960f4c5e087ed867
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08975288B2

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