4-Chloro-2-nitrobenzonitrile → 2-Nitro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile

참여 물질

역할	이름	HCID	투입량
반응물	4-Chloro-2-nitrobenzonitrile	HCID 96924	—
반응물	1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole	HCID 11587208	—
생성물	2-Nitro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile	HCID 67171529	—

반응 단계

The title compound was prepared from 4-chloro-2-nitrobenzonitrile (1.50 g) and 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxa-borolan-2-yl)-1H-pyrazole (2.74 g) using the method of Example 39(a). Yield 1.75 g. 1H-NMR (400 MHz; d6-DMSO): δ 1.57 (m, 3H), 1.84 (m, 1H), 1.97 (m, 1H), 2.38-2.47 (m, 1H), 3.68-3.75 (m, 1H), 4.03 (m, 1H), 5.33 (dd, 1H), 6.84 (d, 1H), 7.69 (d, 1H), 8.13 (dd, 1H), 8.31 (d, 1H), 8.60 (d, 1H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08975254B2
출처 데이터셋	uspto-grants-2015_03
ORD ID	ord-d8cffdcfc210486597b6549f93daa1b7
출처 메모	uspto-grants-2015_03