N-Boc-(R)-1-amino-2-propanol → (R)-4-(1-(1-aminopropan-2-yl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile

HRID 872800노트

반응식

HRID 872800 반응식
[Cl:1][C:2]1[CH:9]=[C:8]([C:10]2[CH:14]=[CH:13][NH:12][N:11]=2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].O[C@H:16]([CH3:26])[CH2:17][NH:18]C(=O)OC(C)(C)C>>[NH2:18][CH2:17][C@H:16]([N:12]1[CH:13]=[CH:14][C:10]([C:8]2[CH:7]=[CH:6][C:3]([C:4]#[N:5])=[C:2]([Cl:1])[CH:9]=2)=[N:11]1)[CH3:26]

참가 물질

3

반응물 2

HCID 12094522N-Boc-(R)-1-amino-2-propanolHCID 178509585HCID 178509585, 화합물

생성물 1

HCID 67172099(R)-4-(1-(1-aminopropan-2-yl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile

실험 절차

(R)-4-[1-(1-Aminopropan-2-yl)-1H-pyrazol-3-yl]-2-chlorobenzonitrile was prepared using the method of Example 34(c) starting from 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile and (R)-tert-butyl 2-hydroxypropylcarbamate. 1H NMR (400 MHz, CDCl3): 1.24 (21-1, broad s), 1.54 (3H, d), 3.05 (1H, distorted dd), 3.17 (1H, distorted dd), 4.34 (1H, m), 6.61 (1H, d), 7.52 (1H, d), 7.66 (1H, d), 7.78 (1H, dd), 7.98 (1H, d).

출처 및 근거

ORD 기록
ord-534dce452b334fc7bb28a7221e85634b
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08975254B2

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