Ethanol → HCID 178470503, 화합물

HRID 872919노트

반응식

HRID 872919 반응식
CCOC([CH2:6][CH2:7][C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=O)=O.Cl.Cl.[NH2:17][NH2:18].[OH2:19].[C:20]([O-])(O)=O.[Na+].[CH2:25](O)[CH3:26]>>[CH2:25]([O:19][C:20]1[NH:18][N:17]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[C:7]=1[CH3:6])[CH3:26]

참가 물질

6

반응물 5

HCID 702EthanolHCID 962WaterHCID 17548Hydrazine, dihydrochlorideHCID 800701,5-Diethyl 2-oxopentanedioateHCID 516892Sodium Bicarbonate

생성물 1

HCID 178470503HCID 178470503, 화합물수율 80%

실험 절차

A solution of diethyl oxalpropionate (9.15 ml, 49.5 mmol) and hydrazine dihydrochloride (6.23 g, 59.3 mmol) in ethanol (50 ml) was refluxed for 1 h. The mixture was then cooled and water (150 ml) was added. The solution was neutralised with solid NaHCO3 and extracted four times with EtOAc. The organic phase was washed with brine and water, dried with Na2SO4 and evaporated to dryness affording 7.81 g (80%) of the title compound. LC-MS: [M+1]=199.22.

후처리

  1. temperatureThe mixture was then cooled
  2. extractionextracted four times with EtOAc
  3. washThe organic phase was washed with brine and water
  4. dry with materialdried with Na2SO4
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-ff515dbe94454f91bfb10d0602cd17dc
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08975254B2

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