Morpholine → 1-Morpholin-4-yl-[2,6]naphthyridine

HRID 8738노트

반응식

HRID 8738 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][N:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[N:12]1([C:2]2[C:11]3[C:6](=[CH:7][N:8]=[CH:9][CH:10]=3)[CH:5]=[CH:4][N:3]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 128847741-Chloro-2,6-naphthyridine

생성물 1

HCID 219836751-Morpholin-4-yl-[2,6]naphthyridine

실험 절차

To 1-chloro-2,6-naphthyridine (164.3 mg, 0.998 mmol) (prepared as described in Van den Haak et al, J. Org. Chem 1982, 47 (9), 1673–7) was added morpholine (15 mL) and the mixture was heated at reflux for 4 h. Removal of the volatile components gave 216.6 mg of 1-morpholin-4-yl-[2,6]naphthyridine as a beige solid.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 4 h
  3. customRemoval of the volatile components

출처 및 근거

ORD 기록
ord-617f60e42998408eb2d6587c55676ac9
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091200B2

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