(S)-3-(5-(1-methylpyrrolidin-2-yl)pyridin-3-yl)acrylonitrile → (S)-3-(5-(1-methylpyrrolidin-2-yl)pyridin-3-yl)propanenitrile
반응식
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:15]#[N:16])[CH:10]=[N:11][CH:12]=1>CO.[Pd]>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[C:7]1[CH:8]=[C:9]([CH2:13][CH2:14][C:15]#[N:16])[CH:10]=[N:11][CH:12]=1참가 물질
4
실험 절차
(S)-3-(5-(1-Methylpyrrolidin-2-yl)pyridin-3-yl)acrylonitrile (preparation 2) (185 mg, 0.87 mmol) and 5% Pd/C (50 mg) in MeOH (5 mL) were stirred under an atmosphere of hydrogen for 72 hours. The reaction mixture was filtered through Celite then the solvent evaporated. The crude product was purified by flash chromatography (5% [20% ammonia in MeOH] in DCM) to give the title compound as a pale yellow oil (141 mg, 75%).
후처리
- filtrationThe reaction mixture was filtered through Celite
- customthe solvent evaporated
- customThe crude product was purified by flash chromatography (5% [20% ammonia in MeOH] in DCM)
출처 및 근거
- ORD 기록
- ord-1eb61d0a62c54ee99e5831e557af821f
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08980276B2
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