Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylsilyldiazomethane → 1-N-Boc-4-Piperidinecarboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 반응물 | 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid | HCID 392871 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | 1-N-Boc-4-Piperidinecarboxylic acid methyl ester | HCID 392870 | 96.6% |
반응 단계
To a solution of BOC-isonipecotic acid (45.0 g, 0.20 mol) dissolved in a 3:1 solution of dichloromethane/methanol (1200 mL) at 0° C. was added a solution of trimethylsilyldiazomethane (147 mL, 0.29 mol, 2.0M in hexane) over 30 min via an addition funnel. The reaction mixture was then concentrated to afford the title compound (47 g) as a light yellow oil. This was used directly in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091211B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-b2d23674e1954e95b0862e72fba9eb4a |
| 출처 메모 | uspto-grants-2006_08 |