4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid → 4-(6-cyanopyridin-2-yl)-1-methyl-1H-pyrazole-5-carboxylic acid

반응식

Br[C:2]1[N:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][CH:3]=1.I[C:11]1[CH:12]=[N:13][N:14]([CH3:19])[C:15]=1[C:16]([OH:18])=[O:17]>>[C:8]([C:6]1[N:7]=[C:2]([C:11]2[CH:12]=[N:13][N:14]([CH3:19])[C:15]=2[C:16]([OH:18])=[O:17])[CH:3]=[CH:4][CH:5]=1)#[N:9]

참가 물질

반응물 2

HCID 6736874-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid

HCID 151008596-Bromopyridine-2-carbonitrile

생성물 1

HCID 903834544-(6-cyanopyridin-2-yl)-1-methyl-1H-pyrazole-5-carboxylic acid수율 0.5%

실험 절차

Using 6-bromopicolinonitrile (0.73 g) and 4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid (1 g), the title compound (4.7 mg) was obtained in the form of a colorless solid by the same method as that of (Example 3.22) <Step 1> or a method equivalent thereto.

출처 및 근거

ORD 기록: ord-db62c6dc65dc4055b9f9ca1ebb41ec75
출처 데이터셋: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08980888B2

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