Dimethylformamide → 1-Bromo-4-((methylsulfonyl)methyl)benzene

HRID 874461노트

반응식

HRID 874461 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.CN(C)C=O.[CH3:15][S:16]([O-:18])=[O:17].[Na+]>O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][S:16]([CH3:15])(=[O:18])=[O:17])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 685274-Bromobenzyl bromideHCID 2733271Sodium methanesulfinate

생성물 1

HCID 27614151-Bromo-4-((methylsulfonyl)methyl)benzene수율 95.3%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
65 °C

실험 절차

A 250 mL round-bottomed flask was charged with 4-bromobenzyl bromide (5 g, 20 mmol) and N,N-dimethylformamide (10.81 mL). Sodium methanesulfinate (3.06 g, 30 mmol) was added. The reaction mixture was stirred at 65° C. for 1 hour. The reaction mixture was cooled to ambient temperature and diluted with water. The resulting suspension was stirred for 10 minutes and filtered. The solid was rinsed with water and dried under house vacuum over the weekend to provide 4.75 g (95%) of the title compound.

후처리

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. stirringThe resulting suspension was stirred for 10 minutes
  3. filtrationfiltered
  4. washThe solid was rinsed with water
  5. customdried under house vacuum over the weekend

출처 및 근거

ORD 기록
ord-aadcf15d758546bbb4417297c61dfe81
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08980879B2

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