m-Chloroperbenzoic acid → N-benzyl-4-(3-chloro-4-methoxybenzyloxy)-2-(methylsulfinyl) pyrimidine-5-carboxamide
반응식
[CH2:1]([NH:8][C:9]([C:11]1[C:12]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([Cl:29])[CH:22]=2)=[N:13][C:14]([S:17][CH3:18])=[N:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1C=C(Cl)C=C(C(OO)=[O:38])C=1>ClCCl>[CH2:1]([NH:8][C:9]([C:11]1[C:12]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([Cl:29])[CH:22]=2)=[N:13][C:14]([S:17]([CH3:18])=[O:38])=[N:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
N-benzyl-4-(3-chloro-4-methoxybenzyloxy)-2-(methylmercapto)pyrimidine-5-carboxamide (100 mg, 0.23 mmol) was dissolved in 10 mL of dichloromethane, m-CPBA (m-chloroperbenzoic acid, 40 mg, 0.23 mmol) was added and reacted at room temperature for 3 h, washed with water after the reaction is complete, extracted with dichloromethane, the organic layer was dried and dried by rotation to obtain yellow solid, and this product was directly used in the next reaction without purification.