m-Chloroperbenzoic acid → 4-(3-chloro-4-methoxybenzyloxy)-2-(methylsulfinyl)-N-(pyridin-2-ylmethyl)pyrimidine-5-carboxamide

HRID 874512노트

반응식

HRID 874512 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])[CH2:5][O:6][C:7]1[C:12]([C:13]([NH:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)=[O:14])=[CH:11][N:10]=[C:9]([S:23][CH3:24])[N:8]=1.C1C=C(Cl)C=C(C(OO)=[O:38])C=1>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][C:27]=1[O:28][CH3:29])[CH2:5][O:6][C:7]1[C:12]([C:13]([NH:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)=[O:14])=[CH:11][N:10]=[C:9]([S:23]([CH3:24])=[O:38])[N:8]=1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 712351214-(3-chloro-4-methoxybenzyloxy)-2-(methylmercapto)-N-(pyridin-2-ylmethyl)pyrimidine-5-carboxamide

생성물 1

HCID 712351224-(3-chloro-4-methoxybenzyloxy)-2-(methylsulfinyl)-N-(pyridin-2-ylmethyl)pyrimidine-5-carboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-(3-chloro-4-methoxybenzyloxy)-2-(methylmercapto)-N-(pyridin-2-ylmethyl)pyrimidine-5-carboxamide (180 mg, 0.42 mmol) was dissolved in 20 ml of dichloromethane, m-CPBA (80 mg, 0.46 mmol) was added and reacted at room temperature for 12 h, washed with water after reaction, extracted with dichloromethane, the organic layer was dried, dried by rotation to obtain yellow solid, and this product was directly used in the next reaction without purification.

후처리

  1. customreacted at room temperature for 12 h
  2. washwashed with water
  3. customafter reaction
  4. extractionextracted with dichloromethane
  5. customthe organic layer was dried
  6. customdried by rotation
  7. customto obtain yellow solid
  8. customthis product was directly used in the next reaction without purification

출처 및 근거

ORD 기록
ord-0b6beac62e3b44dea5cd5d781ce01305
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08980904B2

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