1,4-Dioxane hydrochloride → 3-(1,3-Dioxolan-2-yl)propyl piperidine-4-carboxylate hydrochloride

반응식

[ClH:1].O1CCOCC1.[N:8]1(C(OC(C)(C)C)=O)[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH2:18][CH2:19][CH:20]2[O:24][CH2:23][CH2:22][O:21]2)=[O:15])[CH2:10][CH2:9]1>>[ClH:1].[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH2:18][CH2:19][CH:20]2[O:21][CH2:22][CH2:23][O:24]2)=[O:15])[CH2:10][CH2:9]1

참가 물질

반응물 2

HCID 204431481,4-Dioxane hydrochloride

HCID 867223024-(3-(1,3-Dioxolan-2-yl)propyl) 1-tert-butyl piperidine-1,4-dicarboxylate

생성물 1

HCID 867223013-(1,3-Dioxolan-2-yl)propyl piperidine-4-carboxylate hydrochloride

실험 절차

HCl-dioxane (4 M, 5 mL, 20 mmol) was added to 4-(3-(1,3-dioxolan-2-yl)propyl) 1-tert-butyl piperidine-1,4-dicarboxylate (0.71 g, 2.07 mmol) and the reaction mixture was stirred at RT for 1.5 hours. The solvent was evaporated at reduced pressure. The crude material was used directly without purification.

후처리

customThe solvent was evaporated at reduced pressure
customThe crude material was used directly without purification

출처 및 근거

ORD 기록: ord-4c82da05561c40a7bd066f923e983a6d
출처 데이터셋: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08980913B2

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