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Trifluoroacetic acid → 2-[2-benzyloxy-1-(7H-pyrrolo[2,3-d]pyrimdin-4-ylamino)-ethyl]-5-methyl-3-phenyl-3H-quinazolin-4-one

HRID 874873
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HRID 874873 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:31])[N:5]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:6]([CH:12]([NH:15][C:16]1[N:24]=[CH:23][N:22]=[C:21]3[C:17]=1N=[CH:19][NH:20]3)[CH2:13]C)=[N:7]2.O=C1CCC(=O)N1OC(=O)C(NC(OC(C)(C)C)=O)C[O:43][CH2:44][C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1.O=[C:61]1CCC(=O)N1OC(=O)C(NC(OCC1C=CC=CC=1)=O)CC.C(O)(C(F)(F)F)=O.ClC1C2C=CNC=2N=CN=1.BrC1N=CN=C2C=1NC=N2>>[CH2:44]([O:43][CH2:13][CH:12]([C:6]1[N:5]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:4](=[O:31])[C:3]2[C:8](=[CH:9][CH:10]=[CH:11][C:2]=2[CH3:1])[N:7]=1)[NH:15][C:16]1[C:17]2[CH:61]=[CH:19][NH:20][C:21]=2[N:22]=[CH:23][N:24]=1)[C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1
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참가 물질

7

반응물 6

HCID 6422Trifluoroacetic acidHCID 333593(2,5-Dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylmethoxypropanoateHCID 5287830Purine, 6-bromo-HCID 53566827H-Pyrrolo(2,3-d)pyrimidine, 4-chloro-HCID 12961228(2,5-Dioxopyrrolidin-1-yl) 2-(phenylmethoxycarbonylamino)butanoateHCID 178456854HCID 178456854, 화합물

생성물 1

HCID 115914642-[2-benzyloxy-1-(7H-pyrrolo[2,3-d]pyrimdin-4-ylamino)-ethyl]-5-methyl-3-phenyl-3H-quinazolin-4-one

실험 절차

Compound 30 was prepared using the general procedure described above with respect to compound 14, but 3-benzyloxy-2-tert-butoxycarbonylaminopropionic acid 2,5-dioxo-pyrrolidin-1-yl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidin-1-yl ester in step B, the alternate procedure (TFA deprotection) was used in step C, and 4-chloro-7H-pyrrolo[2,3-d]pyrimidine was substituted for 6-bromopurine in step D. MS (ES): m/z 503 (M+H), 395. Compound 30is shown below.

출처 및 근거

ORD 기록
ord-1ec3fd36bbb14d649a6859fe5dfb8976
출처 데이터셋
uspto-grants-2015_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08980901B2

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