Cesium carbonate → 2-anilino-5,6,8,9,10,11-hexahydro-7H-[1,4]diazepino[1',2':1,5]pyrazolo[4,3-h]quinazolin-7-one

HRID 875132노트

반응식

HRID 875132 반응식
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:25]([C:26]([O:28]CC)=O)=[C:9]2[CH2:10][CH2:11][C:12]3[CH:13]=[N:14][C:15]([NH:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[N:16][C:17]=3[C:8]2=[N:7]1.C(=O)([O-])[O-].[Cs+].[Cs+]>CO>[NH:18]([C:15]1[N:14]=[CH:13][C:12]2[CH2:11][CH2:10][C:9]3=[C:25]4[C:26](=[O:28])[NH:2][CH2:3][CH2:4][CH2:5][N:6]4[N:7]=[C:8]3[C:17]=2[N:16]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

4

반응물 2

HCID 10796Cesium carbonateHCID 68937619HCID 68937619, 화합물

생성물 1

HCID 575317242-anilino-5,6,8,9,10,11-hexahydro-7H-[1,4]diazepino[1',2':1,5]pyrazolo[4,3-h]quinazolin-7-one수율 70%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

185 mg (0.43 mmol) of ethyl 2-(3-aminopropyl)-8-anilino-4,5-dihydro-2H-pyrazolo[4,3-h]quinazoline-3-carboxylate hydrochloride were dissolved in 10 mL of methanol and 400 mg of cesium carbonate were added. After 3 hours under stirring at room temperature the solvent was removed at reduced pressure. Water was then added to the residue and the solid collected by filtration and washed with water and acetone to give 100 mg (70% yield) of the title compound.

후처리

  1. customwas removed at reduced pressure
  2. additionWater was then added to the residue
  3. filtrationthe solid collected by filtration
  4. washwashed with water and acetone

출처 및 근거

ORD 기록
ord-841775ec7f8e42678c7fd4a71f37a993
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08981089B2

반응 노트

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