Thionyl Chloride → 2,6-Dichloro-4-(methylcarbamoyl)benzoyl chloride

HRID 875387노트

반응식

HRID 875387 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:14])[NH:12][CH3:13])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:18])=O>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([C:11](=[O:14])[NH:12][CH3:13])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4]([Cl:18])=[O:5]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 710616332,6-Dichloro-4-(methylcarbamoyl)benzoic acid

생성물 1

HCID 867206232,6-Dichloro-4-(methylcarbamoyl)benzoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
50 °C

실험 절차

A mixture of 2,6-dichloro-4-(methylcarbamoyl)benzoic acid (400 mg, 1.6 mmol) and thionyl chloride (1.91 g, 16 mmol) in dichloromethane (10 mL) was stirred at 50° C. for 5 hours. The reaction mixture was concentrated under rotary evaporator and used as such for next step.

후처리

  1. concentrationThe reaction mixture was concentrated under rotary evaporator

출처 및 근거

ORD 기록
ord-7bf75a3ddfa543169c0fdcf7e0d18d11
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08980911B2

반응 노트

불러오는 중…