5-Azaindole → 3,5-Dichloro-4-(1H-pyrrolo[3,2-c]pyridin-1-ylcarbonyl)benzonitrile

반응식

[NH:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[CH:2]1.[Cl:10][C:11]1[CH:19]=[C:18]([C:20]#[N:21])[CH:17]=[C:16]([Cl:22])[C:12]=1[C:13](O)=[O:14]>>[Cl:10][C:11]1[CH:19]=[C:18]([CH:17]=[C:16]([Cl:22])[C:12]=1[C:13]([N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[CH:2]1)=[O:14])[C:20]#[N:21]

참가 물질

반응물 2

HCID 92205-Azaindole

HCID 178550602,6-Dichloro-4-cyanobenzoic acid

생성물 1

HCID 716186173,5-Dichloro-4-(1H-pyrrolo[3,2-c]pyridin-1-ylcarbonyl)benzonitrile

실험 절차

3,5-Dichloro-4-(1H-pyrrolo[3,2-c]pyridin-1-ylcarbonyl)benzonitrile (Compound No. 95) was prepared using 1H-pyrrolo[3,2-c]pyridine and 2,6-dichloro-4-cyanobenzoic acid.

출처 및 근거

ORD 기록: ord-4b87e723fd3545df9a53f8c889c30caf
출처 데이터셋: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08980911B2

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