1-Bromopentane → 2-(3-(3-(Pentyloxy)phenyl)propyl)isoindoline-1,3-dione

HRID 875518

반응식

HRID 875518 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]2=[O:21])[CH:5]=[CH:6][CH:7]=1.[CH2:22](Br)[CH2:23][CH2:24][CH2:25][CH3:26]>>[CH2:22]([O:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]2=[O:21])[CH:5]=[CH:6][CH:7]=1)[CH2:23][CH2:24][CH2:25][CH3:26]

참가 물질

3

반응물 2

HCID 80571-BromopentaneHCID 580275422-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione

생성물 1

HCID 673154642-(3-(3-(Pentyloxy)phenyl)propyl)isoindoline-1,3-dione

실험 절차

Alkylation reaction of phenol 58 with pentyl bromide gave 2-(3-(3-(pentyloxy)phenyl)propyl)isoindoline-1,3-dione as yellow oil. Yield (0.549 g, 46%): 1H NMR (400 MHz, CDCl3) δ 7.81-7.84 (m, 2H), 7.69-7.72 (m, 2H), 7.11-7.16 (m, 1H), 6.76 (d, J=7.6 Hz, 1H), 6.73 (s, 1H), 6.66 (dd, J=7.8, 2.2 Hz, 1H), 3.91 (t, J=6.8 Hz, 2H), 3.74 (t, J=7.2 Hz, 2H), 2.65 (t, J=7.6 Hz, 2H), 2.01-2.07 (m, 2H), 1.73-1.78 (m, 2H), 1.34-1.48 (m, 4H), 0.92 (t, J=7.2 Hz, 3H).

출처 및 근거

ORD 기록
ord-9eb2dfe5a8a947cea43b364c71282db2
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08981153B2

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