Styrene Oxide → 2-(3-(3-(2-Hydroxy-2-phenylethoxy)phenyl)propyl)isoindoline-1,3-dione

HRID 875576

반응식

HRID 875576 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]2=[O:21])[CH:5]=[CH:6][CH:7]=1.[CH2:22]1[O:30][CH:23]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[OH:30][CH:23]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:22][O:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]2=[O:21])[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 7276Styrene OxideHCID 580275422-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione

생성물 1

HCID 673178412-(3-(3-(2-Hydroxy-2-phenylethoxy)phenyl)propyl)isoindoline-1,3-dione

실험 절차

Alkylation reaction of phenol 58 with styrene oxide gave 2-(3-(3-(2-hydroxy-2-phenylethoxy)phenyl)propyl)isoindoline-1,3-dione as yellow oil. Yield (0.78 g, 58%): 1H NMR (400 MHz, CDCl3) δ 7.50-7.54 (m, 2H), 7.42-7.47 (m, 2H), 7.31-7.41 (m, 5H), 7.16-7.20 (m, 1H), 6.80-6.84 (m, 2H), 6.71 (dd, J=8.4, 2.2 Hz, 1H), 5.10 (dd, J=8.4, 3.2 Hz, 1H), 4.08 (d, J=6.4 Hz, 2H), 3.44-3.49 (m, 2H), 2.68 (t, J=7.4 Hz, 2H), 1.90-1.98 (m, 2H).

출처 및 근거

ORD 기록
ord-b6fb2a36681c4ed1855b4dd52f2c25ab
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08981153B2

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