Tert-butyl trans-1-benzyl-4-cyclopropylpiperidin-3-ylcarbamate → Tert-butyl-trans-4-cyclopropylpiperidin-3-ylcarbamate

HRID 875642노트

반응식

HRID 875642 반응식
C([N:8]1[CH2:13][CH2:12][C@@H:11]([CH:14]2[CH2:16][CH2:15]2)[C@H:10]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[C:20]([O:19][C:18](=[O:24])[NH:17][C@H:10]1[C@H:11]([CH:14]2[CH2:15][CH2:16]2)[CH2:12][CH2:13][NH:8][CH2:9]1)([CH3:23])([CH3:21])[CH3:22]

참가 물질

5

반응물 2

HCID 67045345Tert-butyl trans-1-benzyl-4-cyclopropylpiperidin-3-ylcarbamateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 86652140Tert-butyl-trans-4-cyclopropylpiperidin-3-ylcarbamate수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of tert-butyl trans-1-benzyl-4-cyclopropylpiperidin-3-ylcarbamate (1.20 g, 3.63 mmol) and 10% Pd/C (0.39 g, 0.36 mmol) in methanol (20 mL) was charged with 1 atmosphere hydrogen and stirred at room temperature for 18 hours. The catalyst was removed by filtration and washed with methanol (20 mL). The filtrate was concentrated in vacuo to give tert-butyl-trans-4-cyclopropylpiperidin-3-ylcarbamate (0.87 g, 100%) as a solid.

후처리

  1. customThe catalyst was removed by filtration
  2. washwashed with methanol (20 mL)
  3. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-c02c5d335cad40278930d92262b55896
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08981085B2

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