Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Amantadine Hydrochloride → 6-chloro-N-(1-Adamantyl)pyrimidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Amantadine Hydrochloride | HCID 64150 | — |
| 반응물 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 6-chloro-N-(1-Adamantyl)pyrimidin-4-amine | HCID 53486071 | — |
반응 단계
200 mg of 4,6-dichloropyrimidine, 252 mg of 1-aminoadamantane hydrochloride and 452 mg of DIPEA were dissolved in 2 mL of i-PrOH and the mixture obtained was charged into a screw cap vial and the vial was kept overnight in a heating block at 90° C. The reaction was monitored by TLC and was completed after 12 hours. The mixture obtained was cooled to r.t., solvent was evaporated and N-adamant-1-yl-6-chloropyrimidin-4-amine was obtained by column chromatography using PE:EtOAc 10:1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08986994B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-228abab036764f349acb295748861d3d |
| 출처 메모 | uspto-grants-2015_03 |