N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide → N-{5-[3-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide

HRID 876245노트

반응식

HRID 876245 반응식
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:12]=[N:13][CH:14]=2)[CH:6]=[CH:7][CH:8]=1>C(O)(=O)C>[F:24][C:2]([F:1])([F:25])[C:3]1[CH:4]=[C:5]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([NH:15][C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:23])[CH2:10]2)[CH:6]=[CH:7][CH:8]=1

참가 물질

3

반응물 1

HCID 66701292N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide

생성물 1

HCID 66701267N-{5-[3-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 840 mg (1.82 mmol) of N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide in 100 ml of glacial acetic acid was reacted according to General Method 6A. The solution was concentrated under reduced pressure. The product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 700 mg

후처리

  1. concentrationThe solution was concentrated under reduced pressure
  2. customThe product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient)

출처 및 근거

ORD 기록
ord-31b0e3a16f834997a2d8c9fbf8810897
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987248B2

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