Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Chloronicotinic acid → 5-Chloro-N-[1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]pyridine-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Chloronicotinic acid | HCID 247986 | — |
| 반응물 | 1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate | HCID 66701344 | — |
| 생성물 | 5-Chloro-N-[1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]pyridine-3-carboxamide | HCID 46931745 | — |
반응 단계
65 mg (0.15 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate (Example 8A) and 21 mg (0.13 mmol, 0.9 eq.) of 5-chloropyridine-3-carboxylic acid were reacted according to General Method 1. Yield: 39 mg (62% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08987248B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-dbf24134a32a45f1ac814cab6ee02d4e |
| 출처 메모 | uspto-grants-2015_03 |