반응식
FC(F)(F)C(O)=O.[CH:8]1([C:13]([N:15]2[CH2:20][CH:19]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH3:28])=[CH:23][CH:22]=3)[CH2:18][CH:17]([NH2:29])[CH2:16]2)=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]1.[Cl:30][C:31]1[S:35][C:34]([C:36](O)=[O:37])=[CH:33][CH:32]=1>>[Cl:30][C:31]1[S:35][C:34]([C:36]([NH:29][CH:17]2[CH2:18][CH:19]([C:21]3[CH:22]=[CH:23][C:24]([CH2:27][CH3:28])=[CH:25][CH:26]=3)[CH2:20][N:15]([C:13]([CH:8]3[CH2:9][CH2:10][CH2:11][CH2:12]3)=[O:14])[CH2:16]2)=[O:37])=[CH:33][CH:32]=1참가 물질
3
실험 절차
65 mg (0.15 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate (Example 8A) and 22 mg (0.13 mmol, 0.9 eq.) of 5-chlorothiophene-2-carboxylic acid were reacted according to General Method 1. Yield: 43 mg (72% of theory)
출처 및 근거
- ORD 기록
- ord-55fae705e0bf4f34871c63b546abee94
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08987248B2
연결된 노트
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