Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl-1,3-thiazole-5-carboxylic acid → N-[1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]-2,4-dimethyl-1,3-thiazole-5-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl-1,3-thiazole-5-carboxylic acid | HCID 736488 | — |
| 반응물 | 1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate | HCID 66701344 | — |
| 생성물 | N-[1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]-2,4-dimethyl-1,3-thiazole-5-carboxamide | HCID 66761399 | — |
반응 단계
65 mg (0.15 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-amine trifluoroacetate (Example 8A) and 21 mg (0.13 mmol, 0.9 eq.) of 2,4-dimethyl-1,3-thiazole-5-carboxylic acid were reacted according to General Method 1. Yield: 43 mg (73% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08987248B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-f0b58fa1aebb4dda8f9a3438cb639575 |
| 출처 메모 | uspto-grants-2015_03 |