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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → N-{1-[(4-Oxopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}cyclopentanecarboxamide

HRID 876348
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HRID 876348 반응식
C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.O1[C:22]2([CH2:27][CH2:26][N:25]([C:28]([N:30]3[CH2:35][CH:34]([C:36]4[CH:41]=[CH:40][C:39]([C:42]([F:45])([F:44])[F:43])=[CH:38][CH:37]=4)[CH2:33][CH:32]([NH:46][C:47]([CH:49]4[CH2:53][CH2:52][CH2:51][CH2:50]4)=[O:48])[CH2:31]3)=[O:29])[CH2:24][CH2:23]2)[O:21]CC1>CC(C)=O.O>[O:21]=[C:22]1[CH2:27][CH2:26][N:25]([C:28]([N:30]2[CH2:35][CH:34]([C:36]3[CH:41]=[CH:40][C:39]([C:42]([F:45])([F:43])[F:44])=[CH:38][CH:37]=3)[CH2:33][CH:32]([NH:46][C:47]([CH:49]3[CH2:53][CH2:52][CH2:51][CH2:50]3)=[O:48])[CH2:31]2)=[O:29])[CH2:24][CH2:23]1
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참가 물질

4

반응물 2

HCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)2회HCID 66701500N-{1-(1,4-Dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}-cyclopentanecarboxamide

생성물 1

HCID 46931417N-{1-[(4-Oxopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}cyclopentanecarboxamide

시약·촉매·용매 1

HCID 18366337Propan-2-one--water (1/1)용매

실험 절차

14.3 mg of pyridinium p-toluenesulphonate (0.057 mmol) were added to a solution of the acetal from Example 63A (97.2 mg, 0.191 mmol) in 5.5 ml of acetone/water (10:1), and the mixture was stirred under reflux overnight. Another 14.3 mg of pyridinium p-toluenesulphonate (0.057 mmol) were added, and the mixture was stirred under reflux for another night. The mixture was then cooled, and the precipitate formed was filtered off. Yield: 66.2 mg (74% of theory)

후처리

  1. temperatureunder reflux overnight
  2. stirringthe mixture was stirred
  3. temperatureunder reflux for another night
  4. temperatureThe mixture was then cooled
  5. customthe precipitate formed
  6. filtrationwas filtered off

출처 및 근거

ORD 기록
ord-d68b0c0211f545a48670a6127fbec740
출처 데이터셋
uspto-grants-2015_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08987248B2

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