3-Acetyl-5-bromo-2-hydroxybenzoic acid → 3-Acetyl-2-hydroxybenzoic acid

HRID 876535노트

반응식

HRID 876535 반응식
[C:1]([C:4]1[C:5]([OH:14])=[C:6]([CH:10]=[C:11](Br)[CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]>C(O)C.[Pd]>[C:1]([C:4]1[C:5]([OH:14])=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 110106863-Acetyl-5-bromo-2-hydroxybenzoic acid

생성물 1

HCID 108992643-Acetyl-2-hydroxybenzoic acid수율 85%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

3-acetyl-5-bromo-2-hydroxybenzoic acid 31 (50 g, 0.19 mol) was dissolved in 250 mL ethanol. After addition of 5.0 g 10% Pd/C the reaction mixture was hydrogenated under 15 atm H2-pressure at room temperature for 6 h. The catalyst was filtered and the solvent was evaporated. The residue was poured into H2O and extracted with CH2Cl2. The combined organic phase was dried and the solvent was removed to give 32 (28 g, 85% yield)

후처리

  1. filtrationThe catalyst was filtered
  2. customthe solvent was evaporated
  3. additionThe residue was poured into H2O
  4. extractionextracted with CH2Cl2
  5. customThe combined organic phase was dried
  6. customthe solvent was removed

출처 및 근거

ORD 기록
ord-43d3767f31fd48d9ab13f969cd83fe22
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987258B2

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