HCID 58290751, 화합물 → HCID 131732592, 화합물

HRID 876631노트

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HRID 876631 반응식
[C:1]([O:4][C@H:5]([C@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:24]=[CH:23][CH:22]=[C:21]3[C:16]=2[CH:17]=[CH:18][C:19](=[O:25])[NH:20]3)[C:10]1=[O:26])[C:6](O)=[O:7])(=[O:3])[CH3:2].[NH2:27][C:28]1[CH:47]=[CH:46][C:31]2[C:32]([N:35]3[C:43](=[O:44])[C:42]4[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=4)[C:36]3=[O:45])=[N:33][O:34][C:30]=2[CH:29]=1>>[O:45]=[C:36]1[C:37]2[C:42](=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:43](=[O:44])[N:35]1[C:32]1[C:31]2[CH:46]=[CH:47][C:28]([NH:27][C:6](=[O:7])[C@H:5]([O:4][C:1](=[O:3])[CH3:2])[C@H:9]3[O:14][CH2:13][CH2:12][N:11]([C:15]4[CH:24]=[CH:23][CH:22]=[C:21]5[C:16]=4[CH:17]=[CH:18][C:19](=[O:25])[NH:20]5)[C:10]3=[O:26])=[CH:29][C:30]=2[O:34][N:33]=1

참가 물질

3

반응물 2

HCID 58290751HCID 58290751, 화합물HCID 67032822HCID 67032822, 화합물

생성물 1

HCID 131732592HCID 131732592, 화합물

실험 절차

According to the Step 15-1 in the synthetic method for Example aa15, (2R)-2-acetyloxy-2-[(2R)-3-oxo-4-(2-oxo-1H-quinolin-5-yl)morpholin-2-yl]acetic acid (compound aa16-4) and 6-amino-3-(1,3-dioxoisoindol-2-yl)-1,2-benzisoxazole can be used to obtain [(1R)-2-[[3-(1,3-dioxoisoindol-2-yl)-1,2-benzisoxazol-6-yl]amino]-2-oxo-1-[(2R)-3-oxo-4-(2-oxo-1H-quinolin-5-yl)morpholin-2-yl]ethyl]acetate (compound ap3-1), then further treatment can be achieved according to the Step 15-2 to obtain the title compound ap3.

출처 및 근거

ORD 기록
ord-132b344ecd814880bf68cb502bb7363e
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987242B2

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