Dimethylformamide diethylacetal → Ethyl 3-(N,N-dimethylamino)-2-(4-cyano-1H-imidazol-1-yl)acrylate

HRID 876681노트

반응식

HRID 876681 반응식
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][N:6]1[CH:10]=[C:9]([C:11]#[N:12])[N:8]=[CH:7]1)[CH3:2].C(O[CH:17](OCC)[N:18]([CH3:20])[CH3:19])C>>[CH2:1]([O:3][C:4](=[O:13])[C:5]([N:6]1[CH:10]=[C:9]([C:11]#[N:12])[N:8]=[CH:7]1)=[CH:17][N:18]([CH3:20])[CH3:19])[CH3:2]

참가 물질

3

반응물 2

HCID 70913Dimethylformamide diethylacetalHCID 68753735ethyl 2-(4-cyano-1H-imidazol-1-yl)acetate

생성물 1

HCID 66726020Ethyl 3-(N,N-dimethylamino)-2-(4-cyano-1H-imidazol-1-yl)acrylate

실험 절차

3.8 g (21.4 mmol) of the compound from Example 33A and 7.4 ml (6.3 g, 42.8 mmol) dimethylformamide diethyl acetal are stirred at a bath temperature of 100° C. for 16 h. For working up, the cooled reaction solution is concentrated on a rotary evaporator and the residue is dried in vacuo.

후처리

  1. customthe cooled reaction solution
  2. concentrationis concentrated on a rotary evaporator
  3. customthe residue is dried in vacuo

출처 및 근거

ORD 기록
ord-b82722f43a034d2fbac56b117e54b805
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987261B2

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