Methanol → thieno[3,2-b]pyridin-2-ylmethanol

HRID 876763노트

반응식

HRID 876763 반응식
[S:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10](OC)=[O:11].[H-].[H-].[H-].[H-].[Li+].[Al+3].CO>C1COCC1>[S:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[CH2:10][OH:11]

참가 물질

5

반응물 3

HCID 887MethanolHCID 21226445Aluminium lithium hydrideHCID 22047416Methyl thieno(3,2-b)pyridine-2-carboxylate

생성물 1

HCID 13220437thieno[3,2-b]pyridin-2-ylmethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
0 °C

실험 절차

To a solution of methyl thieno[3,2-b]pyridine-2-carboxylate (C-3) (600 mg, 3.1 mmol) in 30 mL of anhydrous THF at 0° C. was added LiAlH4 (472 mg, 12.4 mmol) in anhydrous THF (25 mL) dropwise over 20 mins. The reaction mixture was stirred at 0° C. for 30 mins. MeOH was added and the resulting mixture was purified by chromatography to afford the title compound. MS (m/z): 166 (M+1)+.

후처리

  1. customthe resulting mixture was purified by chromatography

출처 및 근거

ORD 기록
ord-2138c7819f3449468214c8c715a61627
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987269B2

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