Aluminium lithium hydride → Thieno[3,2-c]pyridin-2-ylmethanol

HRID 876767노트

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HRID 876767 반응식
[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10](OC)=[O:11].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[CH2:10][OH:11]

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 22047666Methyl thieno[3,2-c]pyridine-2-carboxylate

생성물 1

HCID 46784992Thieno[3,2-c]pyridin-2-ylmethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

To a solution of methyl thieno[3,2-c]pyridine-2-carboxylate (D-2) (15 g, 77.6 mmol) in anhydrous THF (250 mL) was added LiAlH4 (4.42 g, 116.4 mmol) in portions at 0° C. The suspension was stirred at 0° C. for 1 h and then quenched by adding saturated aqueous NH4Cl and filtered. The filtrate was washed with brine and concentrated. The residue was used in the next step without any further purification (10.3 g).

후처리

  1. customquenched
  2. additionby adding saturated aqueous NH4Cl
  3. filtrationfiltered
  4. washThe filtrate was washed with brine
  5. concentrationconcentrated
  6. customThe residue was used in the next step without any further purification (10.3 g)

출처 및 근거

ORD 기록
ord-6b7c4c9efd8e46a58e4caeac72e0c018
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987269B2

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