Oxalyl chloride → Quinoline-6-carbonyl chloride

HRID 876790

반응식

HRID 876790 반응식
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=O)=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.C(Cl)(=O)C([Cl:17])=O>C(Cl)Cl.CN(C=O)C>[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([Cl:17])=[O:13])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 825716-Quinolinecarboxylic acid

생성물 1

HCID 12391963Quinoline-6-carbonyl chloride수율 99.8%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

To a mixture of quinoline-6-carboxylic acid (0-1) (2.0 g, 11.5 mmol) in CH2Cl2 (250 mL) was added 3 drops of DMF at 0° C., followed by oxalyl chloride (7.3 g, 57.5 mmol) dropwise. The resulting reaction was stirred at room temperature overnight, and then concentrated to afford the title compound (2.2 g).

후처리

  1. customThe resulting reaction
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a32c4c7516d54483ba9baf7d0922695d
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987269B2

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