Sodium Methoxide → N-(5-Methoxy-2-nitrophenyl)-S-methyl-L-cysteine

HRID 877

반응식

HRID 877 반응식
F[C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-:18])=[O:17])=[C:6]([NH:8][C@H:9]([C:13]([OH:15])=[O:14])[CH2:10][S:11][CH3:12])[CH:7]=1.[CH3:19][O-:20].[Na+]>CO>[CH3:19][O:20][C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-:18])=[O:17])=[C:6]([NH:8][C@H:9]([C:13]([OH:15])=[O:14])[CH2:10][S:11][CH3:12])[CH:7]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 57293179N-(5-Fluoro-2-nitrophenyl)-S-methyl-L-cysteine

생성물 1

HCID 57147352N-(5-Methoxy-2-nitrophenyl)-S-methyl-L-cysteine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

27 g of N-(5-fluoro-2-nitrophenyl)-S-methyl-L-cysteine (0.1 mol) from Example 1 are dissolved in 150 ml of absolute methanol in a four-necked flask, and 14.4 g of 95% sodium methoxide (0.25 mmol) are added in portions, within the space of 20 minutes and under argon, to this solution while stirring well and while cooling by means of an ice bath. The mixture is then heated to reflux for 2 hours while stirring. TLC monitoring then indicates that the reaction is complete.

후처리

  1. temperaturewhile cooling by means of an ice bath
  2. temperatureThe mixture is then heated
  3. temperatureto reflux for 2 hours
  4. stirringwhile stirring

출처 및 근거

ORD 기록
ord-49f2d19dd08c44a6a1032e78dc4359e1
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723461

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