참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2-Methyl-5-hydroxypyridine | HCID 14275 | — |
| 반응물 | Benzene, 1-chloro-2-methyl-4-nitro- | HCID 83315 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Methyl-5-(2-methyl-4-nitrophenoxy)pyridine | HCID 17990102 | — |
반응 단계
The mixture of 1-chloro-2-methyl-4-nitrobenzene (17.2 g), 6-methylpyridin-3-ol (12 g) and Cs2CO3 (39 g) in DMF (150 mL) was heated at 110° C. for 4 h. The solid was filtered and water (100 mL) and EtOAc (200 mL) were added. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated. The obtained yellow solid was used for the next step directly.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08987284B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_03 |
|---|
| ORD ID | ord-33ca47bf8b6d4e3fa5d1d616b29da37c |
|---|
| 출처 메모 | uspto-grants-2015_03 |
|---|
