Chloroacetyl chloride → N'-(2-chloroacetyl)-2,2-dimethylpropanehydrazide

HRID 877153

반응식

HRID 877153 반응식
[CH3:1][C:2]([CH3:8])([CH3:7])[C:3]([NH:5][NH2:6])=[O:4].[Cl:9][CH2:10][C:11](Cl)=[O:12]>C(OCC)(=O)C>[Cl:9][CH2:10][C:11]([NH:6][NH:5][C:3](=[O:4])[C:2]([CH3:8])([CH3:7])[CH3:1])=[O:12]

참가 물질

4

반응물 2

HCID 6577Chloroacetyl chlorideHCID 5451472,2-Dimethylpropanehydrazide

생성물 1

HCID 54595759N'-(2-chloroacetyl)-2,2-dimethylpropanehydrazide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

5.8 g (49.929 mmol) of 2,2-dimethylpropanehydrazide were dissolved in 600 ml of dry ethyl acetate and heated to reflux. 6.767 g (59.915 mmol) of chloroacetyl chloride, dissolved in 45 ml of dry ethyl acetate, were added dropwise to the solution. The mixture was stirred under reflux for 30 min. After cooling, the reaction mixture was concentrated on a rotary evaporator and the residue was dried under high vacuum. This gave 10.14 g of the title compound. The crude product was reacted further without further purification.

후처리

  1. temperatureheated to reflux
  2. additionwere added dropwise to the solution
  3. temperatureunder reflux for 30 min
  4. temperatureAfter cooling
  5. concentrationthe reaction mixture was concentrated on a rotary evaporator
  6. customthe residue was dried under high vacuum
  7. customThe crude product was reacted further without further purification

출처 및 근거

ORD 기록
ord-5de56236fbe84fa7b3bc245c0078ba42
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987256B2

연결된 노트

불러오는 중…