Methanol → HCID 66893992, 화합물

HRID 877172노트

반응식

S(Cl)([Cl:3])=O.[NH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH:8]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])[CH2:7]1.[CH3:17]O>>[ClH:3].[NH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH:8]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:7]1

참가 물질

반응물 3

HCID 887Methanol

HCID 24386Thionyl Chloride

HCID 4523697HCID 4523697, 화합물

생성물 1

HCID 66893992HCID 66893992, 화합물

실험 절차

At −5° C., 1.9 ml (25.7 mmol) of thionyl chloride were slowly added dropwise to 50 ml of methanol, and the mixture was stirred at this temperature for 10 min. 2 g (11.7 mmol) of 3-(3-aminocyclohexyl)propanoic acid were then added in one portion, and the reaction mixture was stirred at room temperature overnight. After the reaction had gone to completion, the solvent was evaporated under reduced pressure. This gave 2.46 g (11.1 mmol, 95% of theory) of a colorless solid.

후처리

stirringthe reaction mixture was stirred at room temperature overnight
customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록: ord-3478c03fd6ab48f4887030b5cfc5ba15
출처 데이터셋: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08987256B2

반응 노트

불러오는 중…