Tert-butyl(+/-)-3-(3-{[{4-[(acetyloxy)methyl]phenyl}(cyclopentyl)-acetyl]amino}-2-methylphenyl)propanoate → tert-Butyl(+/-)-3-[3-({cyclopentyl[4-(hydroxymethyl)phenyl]acetyl}amino)-2-methylphenyl]propanoate

HRID 877190노트

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HRID 877190 반응식
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([CH:32]2[CH2:36][CH2:35][CH2:34][CH2:33]2)[C:13]([NH:15][C:16]2[C:17]([CH3:31])=[C:18]([CH2:22][CH2:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH:19]=[CH:20][CH:21]=2)=[O:14])=[CH:8][CH:7]=1)(=O)C>N.CO>[CH:32]1([CH:12]([C:9]2[CH:10]=[CH:11][C:6]([CH2:5][OH:4])=[CH:7][CH:8]=2)[C:13]([NH:15][C:16]2[C:17]([CH3:31])=[C:18]([CH2:22][CH2:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH:19]=[CH:20][CH:21]=2)=[O:14])[CH2:36][CH2:35][CH2:34][CH2:33]1

참가 물질

4

반응물 1

HCID 58136347Tert-butyl(+/-)-3-(3-{[{4-[(acetyloxy)methyl]phenyl}(cyclopentyl)-acetyl]amino}-2-methylphenyl)propanoate

생성물 1

HCID 58136762tert-Butyl(+/-)-3-[3-({cyclopentyl[4-(hydroxymethyl)phenyl]acetyl}amino)-2-methylphenyl]propanoate

시약·촉매·용매 2

HCID 222Ammonia용매HCID 887Methanol용매

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온도
35 °C

실험 절차

16.0 g (32.41 mmol) of tert-butyl(+/−)-3-(3-{[{4-[(acetyloxy)methyl]phenyl}(cyclopentyl)-acetyl]amino}-2-methylphenyl)propanoate were dissolved in 300 ml of a 2 M solution of ammonia in methanol and initially stirred at 30-40° C. for 2 h and then overnight at RT. The solution was then concentrated under reduced pressure and the residue was purified by chromatography on silica gel (mobile phase dichloromethane/methanol 100:1). This gave 13.6 g (93.1% of theory) of the title compound.

후처리

  1. customovernight
  2. customat RT
  3. concentrationThe solution was then concentrated under reduced pressure
  4. customthe residue was purified by chromatography on silica gel (mobile phase dichloromethane/methanol 100:1)

출처 및 근거

ORD 기록
ord-ba0cebb5bb914556b274ee72d473c527
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987256B2

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