Sodium Bicarbonate → HCID 68264843, 화합물
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[NH:9]N=C1CCCC1=O.[C:17]([O-:20])(O)=O.[Na+]>CC#N.OS(O)(=O)=O>[Cl:1][C:2]1[C:3]2[NH:9][C:3]3[C:17](=[O:20])[CH2:6][CH2:7][C:2]=3[C:4]=2[CH:5]=[C:6]([Cl:8])[CH:7]=1참가 물질
5
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- 온도
- 80 °C
실험 절차
To a solution of 2-(2-(2,4-dichlorophenyl)hydrazono)cyclopentanone (2.2 g, 8.59 mmol) in MeCN (10 mL), H2SO4 (1.4 mL, 1.8M solution) was added and the mixture stirred at 80° C. for 16 h. The reaction mixture was cooled to room temperature, basified with saturated NaHCO3 and extracted with EtOAc (3×30 mL). The combined organic extracts were dried over Na2SO4 and concentrated in vacuo to give the crude title compound as an off-white solid (800 mg) which was used in the next step without purification.
후처리
- temperatureThe reaction mixture was cooled to room temperature
- extractionextracted with EtOAc (3×30 mL)
- dry with materialThe combined organic extracts were dried over Na2SO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-4016252e89b3443d8ad0c73f244614ca
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08987319B2
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